Severe Refractory Pain
This study is an invasive dual stimulation of both the DLPFC and dACC in an effort to yield improvements in quality of life by targeting both the cognitive and affective components of pain in patients who have extensively failed alternate therapies. We hope to work with patients with post-stroke chronic refractory hemibody pain who have failed previous treatment with medications and spinal cord stimulation. By targeting both the ACC and DLPFC simultaneously, we can comprehensively target all three components of pain and yield improvements in the modulation of pain perception, patient suffering, and pathological cognitive behaviors, while possibly inducing plastic changes in cognitive behavior for better adaptation to residual pain.
UDALL - STUDY AND IMPROVE DBS FOR PARKINSON’S DISEASE
The University of Minnesota (UMN) Udall Center will focus on understanding the electrophysiological features that underlie the motor signs of Parkinson’s disease (PD) and developing new deep brain stimulation (DBS) strategies to treat them by doing cognitive tasks intra-operatively. Our goals are to characterize the role of cognitive hyperdirect pathway (DLPFC- STN) during a behavioral task of variable cognitive effort and compare the independent and synchronized oscillatory lfp activity between STN/GPi and DLPFC during a task of variable cognitive effort with and without DBS stimulation.
NONINVASIVE, EEG, RTMS
This study tests the feasibility of procedures aimed at discovering transdiagnostic biomarkers for cognitive impairment in addiction, depression, pain and spinal cord injury. Participants will take health questionnaires and practice behavioral tasks at home. Subjects will be recruited from Fairview and UMP clinics as well as the community. Eligible populations (starting with 2 distinct populations) will get an MRI for and we will run tasks while recording with EEG plus an rTMS protocol for modulating activity.
MTURK: COGNITIVE AND AFFECTIVE PROCESSES ONLINE
There is a mental health crisis in the United States. We want to identify whether newly designed cognitive tasks sufficiently identify cognitive processes such as working memory, attention, impulsivity and decision making. This online study provides data for evaluating the psychometric characteristics of the included behavioral tests that are used in this lab; providing details about internal consistency, validity, and sensitivity. MTurk, by Amazon, will host Inquisit and Qualtrics tasks and surveys for workers to perform at home for pay. It is expected that about 5,000 people will be in this research study. Each participant can finish the “HIT” in 45 minutes to 1 hour and get paid up to $5.00based on performance and completion. Participation in this study will help neurosurgery and psychiatry researchers better treat mental health and cognitive disorders with deep brain implants.
INVASIVE: MOOD AND COGNITION STUDY
This study explores brain functionality regarding mood, memory, and cognition by collecting behavioral data from computer games played by participants with deep brain implants & EEG monitoring for localization of epileptic seizures.
CORTICAL SPREADING DEPOLARIZATION AFTER TBI
SPINAL CORD STIMULATION