Depression is a common and often serious condition that impacts a variety of aspects of life. Depression can manifest in changes in mood, anxiety, sleep, energy and decision-making ability. These changes can interfere with one’s ability to work or go to school, maintain relationships and feel that life is worth living. Unfortunately, more than a one third of individuals suffering from depression do not benefit from conventional treatment with medications or psychotherapy. Deficits in cognitive functioning and decision-making can be particularly difficult to treat. The Herman-Darrow Lab focuses on the abnormal brain activity that underlies depression and how it affects the circuits of the brain that help us think and make decisions. In particular, we are interested in developing new treatments for those suffering with depression using neuromodulation to improve mood and cognition.